https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Intense sweeteners, taste receptors and the gut microbiome: a metabolic health perspective https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37585 Wed 19 Jan 2022 15:19:31 AEDT ]]> Genomic characterization of the uncultured Bacteroidales family S24-7 inhabiting the guts of homeothermic animals https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25052 Bacteroidales family S24-7 is a prominent example of one of these groups. Marker gene surveys indicate that members of this family are highly localized to the gastrointestinal tracts of homeothermic animals and are increasingly being recognized as a numerically predominant member of the gut microbiota; however, little is known about the nature of their interactions with the host. Results: Here, we provide the first whole genome exploration of this family, for which we propose the name "Candidatus Homeothermaceae," using 30 population genomes extracted from fecal samples of four different animal hosts: human, mouse, koala, and guinea pig. We infer the core metabolism of "Ca. Homeothermaceae" to be that of fermentative or nanaerobic bacteria, resembling that of related Bacteroidales families. In addition, we describe three trophic guilds within the family, plant glycan (hemicellulose and pectin), host glycan, and a-glucan, each broadly defined by increased abundance of enzymes involved in the degradation of particular carbohydrates. Conclusions: "Ca. Homeothermaceae" representatives constitute a substantial component of the murine gut microbiota, as well as being present within the human gut, and this study provides important first insights into the nature of their residency. The presence of trophic guilds within the family indicates the potential for niche partitioning and specific roles for each guild in gut health and dysbiosis.]]> Wed 11 Apr 2018 15:06:09 AEST ]]> Characterisation of the immune cell-microbiome interaction within the gut-lung axis in cigarette smoke induced experimental COPD https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50285 Wed 06 Mar 2024 14:18:15 AEDT ]]> Microbiome and Metabolic Features of Tissues and Feces Reveal Diagnostic Biomarkers For Colorectal Cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50515 Thu 27 Jul 2023 14:34:40 AEST ]]> Gut microbes: heavy metal(loid) interactions https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36013 Thu 20 Feb 2020 11:35:04 AEDT ]]> Protein and carbohydrate intakes alter gut microbial community structure in crickets: a geometric framework approach https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46881 Teleogryllus oceanicus. Our study revealed that species richness decreased as crickets consumed more macronutrients, and species evenness peaked at high intake of protein-rich diets. Sex and protein:carbohydrate (P:C) ratios in diets were the primary factors influencing the gut bacterial community, but most of the microbial operational taxonomic units (OTUs) that were significantly different between males and females were present in low abundance. In contrast, protein intake had a greater influence than carbohydrate consumption on the relative abundances of the core bacterial taxa, as an increase in dietary protein availability could remove the growth constraint imposed by limited nitrogen. Taken together, the use of the Geometric Framework provides a deeper insight into how nutritional intakes influence the relative abundances of gut microbes, and could be a useful tool to integrate the study of gut microbiome and fitness traits in a host.]]> Mon 05 Dec 2022 14:49:21 AEDT ]]> No distinct microbiome signature of irritable bowel syndrome found in a Swedish random population https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46130 Fri 11 Nov 2022 15:21:48 AEDT ]]>